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Últimas noticias de Investigación
26 de abril de 2024
Vía publiDB
Caracterización de biomarcadores de estrés oxidativo en perros. Intervalos de referencia, fuentes de variación biológica e interferencias endógenas
Tesis Doctoral defendida por Blanca Pérez Montero en el Centro VISAVET de la Universidad Computense de Madrid
El estrés oxidativo, definido como un desequilibrio entre los agentes oxidantes y las fuerzas antioxidantes del organismo, se ha relacionado con múltiples patologías en la especie canina. Entre los biomarcadores más utilizados destacan el malondialdehído (MDA), metabolito de la peroxidación lipídica, la 8-hidroxi-2’-deoxiguanosina (8-OHdG), producto de la oxidación del ADN, y el ensayo del ácido 2,2’-azino-di-[3-etilbenzotiazol-6-sulónico] (ABTS) como indicador del estado antioxidante total (TAS). Si bien estos biomarcadores han demostrado valor clínico en perros, destaca la ausencia de interv…
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4 de abril de 2024
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Dinámicas Evolutivas de los Cassettes de Resistencia en Integrones. Profundizando en el Modelo de Integrón
Tesis Doctoral que será defendida por Alberto Hipólito Carrillo de Albornoz en la Facultad de Veterinaria de la Universidad Complutense de Madrid
La resistencia a antimicrobianos es una de las principales amenazas para la salud global del siglo
XXI. El uso indiscriminado de antibióticos, entre otros factores, ha provocado un incremento exponencial de bacterias resistentes a antimicrobianos en las últimas décadas. Se estima que cada año mueren entre
1.5 y 5 millones de personas debido a infecciones causadas por bacterias multirresistentes. Estos datos ponen de manifiesto la necesidad de tomar medidas urgentes para combatir esta amenaza, empezando por entender las fuerzas que rigen el éxito de las bacterias multirresistentes.
La exce…
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2 de abril de 2024
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Active surveillance of antimicrobial resistance in companion animals: A pilot study in a Spanish Veterinary Teaching Hospital
Artículo de investigación publicado en Comparative Immunology, Microbiology and Infectious Diseases
The role of small animal veterinary hospitals in the onset and dissemination of antimicrobial-resistant organisms (AMROs) is still not clear, and the implementation of an internal surveillance systems is a cost-effective tool to better understand their impact. The aim of this study was to describe a pilot program of active surveillance in a Spanish Veterinary Teaching Hospital, developed to estimate the detection frequency of AMROs in the commensal flora of patients and in the environment. Surveillance was focused on Methicillin-resistant Staphylococci (MRS), third generation cephalosporins re…
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2 de abril de 2024
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Forensic findings in urban red fox mortality in the metropolitan area of Madrid, 2014-2022
Artículo de investigación publicado en Journal of Veterinary Diagnostic Investigation
The expanding presence of red foxes (Vulpes vulpes) in urban and suburban regions could potentially lead to increased instances of human aggression towards this species. We studied 10 deceased red foxes that were submitted by law enforcement agencies in the metropolitan area of Madrid in 2014-2022 because of suspected abuse. Forensic autopsies were performed to establish the cause and manner of death. In 4 of the 10 cases, the cause of death was deemed unnatural, involving blunt-force trauma (n = 2), asphyxia resulting from hanging (n = 1), and firearm injury (n = 1). Among the remaining cases…
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27 de marzo de 2024
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Tertiary lymphoid organs in wild boar exposed to a low-virulent isolate of African swine fever virus
Investigación publicada en The Veterinary quarterly
Despite the great interest in the development of a vaccine against African swine fever (ASF) in wild boar, the immunological mechanisms that induce animal protection are still unknown. For this purpose, tertiary lymphoid organs (TLOs) of wild boar were characterised and compared with mucosa-associated lymphoid tissues (MALTs) by histopathology, histomorphometry and immunohistochemistry (CD3, CD79, PAX5, LYVE1, fibronectin). In addition, real-time polymerase chain reaction (qPCR) and immunohistochemistry (p72) were used to evaluate the presence of ASF virus (ASFV) in blood and tissues samples, …
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22 de marzo de 2024
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Eco-Sanitary Regionalization of Wild Boar (Sus scrofa) in the Western Palearctic Realm as a Tool for the Stewardship of African Swine Fever
Investigación publicada en Transboundary and Emerging Diseases
African swine fever (ASF) is a viral hemorrhagic disease affecting domestic and wild suids, with catastrophic socioeconomic impact worldwide. In the European scenario, wild boar (Sus scrofa) actively contributes to the maintenance and spread of the disease. In this study, we applied a multivariate clustering method to define ecoregions in the western Palearctic realm based on ecological and sanitary aspects of ASF in wild boar. Beforehand, we performed a principal components analysis for the eight selected variables. An analysis of the countries was carried out in terms of the extent of ecoreg…
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21 de marzo de 2024
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Estrategias para la prevención de la peste porcina africana
Tesis Doctoral defendida por Carolina Muñoz Peréz en el Centro VISAVET de la Universidad Computense de Madrid
La peste porcina africana (PPA) es una enfermedad infecciosa que afecta tanto a cerdos domésticos como salvajes, y que se encuentra dentro de la lista de enfermedades de declaración obligatoria para la Organización Mundial de Sanidad Animal (WOAH). En los últimos años la enfermedad se ha expandido por todo el mundo convirtiéndose en una pandemia. Una pandemia que supone en la actualidad la mayor amenaza para la producción porcina mundial. En vista de esta situación, la presente tesis doctoral titulada: “Estrategias para la prevención de la peste porcina africana”, persigue el objetivo de obten…
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9 de marzo de 2024
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Molecular detection of herpesvirus in a skin lesion of a humpback whale (Megaptera novaeangliae) from the Western Mediterranean Sea
European Journal of Wildlife Research publica este artículo de investigación
Herpesvirus has the potential to infect a wide variety of animal species. In cetaceans, Alpha- and/or Gammaherpesvirinae have been identified in eight families of odontocetes, and one family of mysticetes. In May 2022, an adult humpback whale (Megaptera novaeangliae) was found stranded in Valencia, Spain. The whale was emaciated, in poor body condition, with multiple lacerations on the dorsal fin and a high number of epibionts of the Cyamidae family, known as whale lice. The individual had been previously released from a ghost net entanglement 5 days before becoming stranded. In a closer exami…
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8 de marzo de 2024
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Pancreatic adenocarcinoma treated with surgical resection, toceranib phosphate and firocoxib in a dog: a case report
Artículo de investigación publicado en Veterinary Research Communications
Exocrine pancreatic carcinomas are rarely reported in dogs. A ductal pancreatic adenocarcinoma in a 10-year-old intact beagle is described in this report. The diagnosis was made based on clinical signs, imaging (abdominal ultrasound and CT scan) and histopathology. Treatment consisted of partial right lobe pancreatectomy followed by adjuvant therapy with toceranib phosphate (Palladia®) and firocoxib (Previcox®) for six months. The treatment was well tolerated, and the survival time was 445 days. To our knowledge, this is the longest survival reported in the literature for a dog diagnosed with …
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4 de marzo de 2024
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Application of machine learning with large-scale data for an effective vaccination against classical swine fever for wild boar in Japan
Artículo de investigación publicado en Scientific reports
Classical swine fever has been spreading across the country since its re-emergence in Japan in 2018. Gifu Prefecture has been working diligently to control the disease through the oral vaccine dissemination targeting wild boars. Although vaccines were sprayed at 14,000 locations between 2019 and 2020, vaccine ingestion by wild boars was only confirmed at 30% of the locations. Here, we predicted the vaccine ingestion rate at each point by Random Forest modeling based on vaccine dissemination data and created prediction surfaces for the probability of vaccine ingestion by wild boar using spatial…
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