Líneas de Investigación
Líneas de investigación del Centro VISAVET
Proyectos de Investigación
Proyectos vigentes en convocatorias públicas
Publicaciones científicas Publicaciones científicas SCI del Centro VISAVET
Tesis
Tesis Doctorales y Disertaciones científicas
del Centro VISAVET
Premios de investigación
Tesis e investigadores premiados
Últimas noticias de Investigación
18 de mayo de 2024
Vía publiDB
Neurobrucellosis (Brucella ceti) in striped dolphins (Stenella coeruleoalba): Immunohistochemical studies on immune response and neuroinflammation
Investigación publicada en Veterinary Pathology
Neurobrucellosis is a shared condition of cetaceans and humans. However, the pathogenesis and immune response in cetacean neurobrucellosis has not been extensively studied. In this multicentric investigation, 21 striped dolphin (Stenella coeruleoalba) neurobrucellosis (Brucella ceti) cases diagnosed over a 10-year period (2012-2022) were retrospectively evaluated. For each case, morphological changes were assessed by evaluating 21 histological parameters. Furthermore, the immunohistochemical expression of Brucella antigen, glial fibrillary acid protein (GFAP), and a selection of inflammatory c…
Leer más
1 de mayo de 2024
Vía publiDB
Detection of equine herpesvirus-1 (EHV-1) in urine samples during outbreaks of equine herpesvirus myeloencephalopathy
Equine veterinary journal publica este artículo de investigación
Background: Real-time PCR is the diagnostic technique of choice for the diagnosis and control of equine herpesvirus-1 (EHV-1) in an outbreak setting. The presence of EHV-1 in nasal swabs (NS), whole blood, brain and spinal cord samples has been extensively described; however, there are no reports on the excretion of EHV-1 in urine, its DNA detection patterns, and the role of urine in viral spread during an outbreak.
Objectives: To determine the presence of EHV-1 DNA in urine during natural infection and to compare the DNA detection patterns of EHV-1 in urine, buffy coat (BC) and NS.
Study de…
Leer más
26 de abril de 2024
Vía publiDB
Caracterización de biomarcadores de estrés oxidativo en perros. Intervalos de referencia, fuentes de variación biológica e interferencias endógenas
Tesis Doctoral defendida por Blanca Pérez Montero en el Centro VISAVET de la Universidad Computense de Madrid
El estrés oxidativo, definido como un desequilibrio entre los agentes oxidantes y las fuerzas antioxidantes del organismo, se ha relacionado con múltiples patologías en la especie canina. Entre los biomarcadores más utilizados destacan el malondialdehído (MDA), metabolito de la peroxidación lipídica, la 8-hidroxi-2’-deoxiguanosina (8-OHdG), producto de la oxidación del ADN, y el ensayo del ácido 2,2’-azino-di-[3-etilbenzotiazol-6-sulónico] (ABTS) como indicador del estado antioxidante total (TAS). Si bien estos biomarcadores han demostrado valor clínico en perros, destaca la ausencia de interv…
Leer más
4 de abril de 2024
Vía publiDB
Dinámicas Evolutivas de los Cassettes de Resistencia en Integrones. Profundizando en el Modelo de Integrón
Tesis Doctoral que será defendida por Alberto Hipólito Carrillo de Albornoz en la Facultad de Veterinaria de la Universidad Complutense de Madrid
La resistencia a antimicrobianos es una de las principales amenazas para la salud global del siglo
XXI. El uso indiscriminado de antibióticos, entre otros factores, ha provocado un incremento exponencial de bacterias resistentes a antimicrobianos en las últimas décadas. Se estima que cada año mueren entre
1.5 y 5 millones de personas debido a infecciones causadas por bacterias multirresistentes. Estos datos ponen de manifiesto la necesidad de tomar medidas urgentes para combatir esta amenaza, empezando por entender las fuerzas que rigen el éxito de las bacterias multirresistentes.
La exce…
Leer más
2 de abril de 2024
Vía publiDB
Active surveillance of antimicrobial resistance in companion animals: A pilot study in a Spanish Veterinary Teaching Hospital
Artículo de investigación publicado en Comparative Immunology, Microbiology and Infectious Diseases
The role of small animal veterinary hospitals in the onset and dissemination of antimicrobial-resistant organisms (AMROs) is still not clear, and the implementation of an internal surveillance systems is a cost-effective tool to better understand their impact. The aim of this study was to describe a pilot program of active surveillance in a Spanish Veterinary Teaching Hospital, developed to estimate the detection frequency of AMROs in the commensal flora of patients and in the environment. Surveillance was focused on Methicillin-resistant Staphylococci (MRS), third generation cephalosporins re…
Leer más
2 de abril de 2024
Vía publiDB
Forensic findings in urban red fox mortality in the metropolitan area of Madrid, 2014-2022
Artículo de investigación publicado en Journal of Veterinary Diagnostic Investigation
The expanding presence of red foxes (Vulpes vulpes) in urban and suburban regions could potentially lead to increased instances of human aggression towards this species. We studied 10 deceased red foxes that were submitted by law enforcement agencies in the metropolitan area of Madrid in 2014-2022 because of suspected abuse. Forensic autopsies were performed to establish the cause and manner of death. In 4 of the 10 cases, the cause of death was deemed unnatural, involving blunt-force trauma (n = 2), asphyxia resulting from hanging (n = 1), and firearm injury (n = 1). Among the remaining cases…
Leer más
27 de marzo de 2024
Vía publiDB
Tertiary lymphoid organs in wild boar exposed to a low-virulent isolate of African swine fever virus
Investigación publicada en The Veterinary quarterly
Despite the great interest in the development of a vaccine against African swine fever (ASF) in wild boar, the immunological mechanisms that induce animal protection are still unknown. For this purpose, tertiary lymphoid organs (TLOs) of wild boar were characterised and compared with mucosa-associated lymphoid tissues (MALTs) by histopathology, histomorphometry and immunohistochemistry (CD3, CD79, PAX5, LYVE1, fibronectin). In addition, real-time polymerase chain reaction (qPCR) and immunohistochemistry (p72) were used to evaluate the presence of ASF virus (ASFV) in blood and tissues samples, …
Leer más
22 de marzo de 2024
Vía publiDB
Eco-Sanitary Regionalization of Wild Boar (Sus scrofa) in the Western Palearctic Realm as a Tool for the Stewardship of African Swine Fever
Investigación publicada en Transboundary and Emerging Diseases
African swine fever (ASF) is a viral hemorrhagic disease affecting domestic and wild suids, with catastrophic socioeconomic impact worldwide. In the European scenario, wild boar (Sus scrofa) actively contributes to the maintenance and spread of the disease. In this study, we applied a multivariate clustering method to define ecoregions in the western Palearctic realm based on ecological and sanitary aspects of ASF in wild boar. Beforehand, we performed a principal components analysis for the eight selected variables. An analysis of the countries was carried out in terms of the extent of ecoreg…
Leer más
21 de marzo de 2024
Vía publiDB
Estrategias para la prevención de la peste porcina africana
Tesis Doctoral defendida por Carolina Muñoz Peréz en el Centro VISAVET de la Universidad Computense de Madrid
La peste porcina africana (PPA) es una enfermedad infecciosa que afecta tanto a cerdos domésticos como salvajes, y que se encuentra dentro de la lista de enfermedades de declaración obligatoria para la Organización Mundial de Sanidad Animal (WOAH). En los últimos años la enfermedad se ha expandido por todo el mundo convirtiéndose en una pandemia. Una pandemia que supone en la actualidad la mayor amenaza para la producción porcina mundial. En vista de esta situación, la presente tesis doctoral titulada: “Estrategias para la prevención de la peste porcina africana”, persigue el objetivo de obten…
Leer más
9 de marzo de 2024
Vía publiDB
Molecular detection of herpesvirus in a skin lesion of a humpback whale (Megaptera novaeangliae) from the Western Mediterranean Sea
European Journal of Wildlife Research publica este artículo de investigación
Herpesvirus has the potential to infect a wide variety of animal species. In cetaceans, Alpha- and/or Gammaherpesvirinae have been identified in eight families of odontocetes, and one family of mysticetes. In May 2022, an adult humpback whale (Megaptera novaeangliae) was found stranded in Valencia, Spain. The whale was emaciated, in poor body condition, with multiple lacerations on the dorsal fin and a high number of epibionts of the Cyamidae family, known as whale lice. The individual had been previously released from a ghost net entanglement 5 days before becoming stranded. In a closer exami…
Leer más
